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EC 2.7.8.43 Details
EC number
2.7.8.43
Accepted name
lipid A phosphoethanolamine transferase
Reaction
(1) diacylphosphatidylethanolamine + lipid A = diacylglycerol + lipid A 1-(2-aminoethyl diphosphate);;(2) diacylphosphatidylethanolamine + lipid A = diacylglycerol + lipid A 4′-(2-aminoethyl diphosphate);;(3) diacylphosphatidylethanolamine + lipid A 1-(2-aminoethyl diphosphate) = diacylglycerol + lipid A 1,4′-bis(2-aminoethyl diphosphate)
Other name(s)
lipid A PEA transferase, LptA
Systematic name
diacylphosphatidylethanolamine:lipid-A ethanolaminephosphotransferase
Comment
The enzyme adds one or two ethanolamine phosphate groups to lipid A giving a diphosphate, sometimes in combination with EC 2.4.2.43 (lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase) giving products with 4-amino-4-deoxy-β-L-arabinose groups at the phosphates of lipid A instead of diphosphoethanolamine groups. It will also act on lipid IVA and Kdo2-lipid A.
History
created 2015 as EC 2.7.4.30, transferred 2016 to EC 2.7.8.43
EC Tree
1.4.1.6 created 1961, deleted 1982
1.6.2.1 created 1961, deleted 1965
1.6.2.3 created 1972, deleted 1965