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EC 1.2.1.50 Details
EC number
1.2.1.50
Accepted name
long-chain acyl-protein thioester reductase
Reaction
a long-chain aldehyde + [protein]-L-cysteine + NADP+ = a [protein]-S-(long-chain fatty acyl)-L-cysteine + NADPH + H+;;
Other name(s)
luxC (gene name), acyl-CoA reductase, acyl coenzyme A reductase, long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming), long-chain-fatty-acyl-CoA reductase
Systematic name
long-chain-aldehyde:NADP+ oxidoreductase (protein thioester-forming)
CAS registry number
50936-56-6
Comment
Together with a hydrolase component (EC 3.1.2.2 and EC 3.1.2.14) and a synthetase component (EC 6.2.1.19), this enzyme forms a multienzyme fatty acid reductase complex that produces the long-chain aldehyde substrate of the bacterial luciferase enzyme (EC 1.14.14.3). The enzyme is acylated by receiving an acyl group from EC 6.2.1.19, and catalyses the reduction of the acyl group, releasing the aldehyde product. The enzyme is also able to accept the acyl group from a long-chain acyl-CoA.
History
created 1986, modified 2016
EC Tree
1.2.1.1 created 1961, modified 1982, modified 2002, deleted 2005
1.2.1.6 created 1961, deleted 1965
1.2.1.14 created 1961, deleted 1984
1.2.1.34 created 1972, deleted 1983 [transferred to EC 1.1.1.180, deleted 1984]
1.2.1.35 created 1972, deleted 1984
1.2.1.37 created 1972, deleted 1984
1.2.1.55 created 1990, deleted 2003
1.2.1.56 created 1990, deleted 2003