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EC 3.1.12.2 Details
show Brenda entryEC number
3.1.12.2
Accepted name
DNA-3′-diphospho-5′-guanosine diphosphatase
Reaction
[DNA]-3′-diphospho-5′-guanosine + H2O = [DNA]-3′-phosphate + GMP
Other name(s)
aprataxin,
DNA-3′pp5′G guanylate hydrolase,
APTX (gene name),
HNT3 (gene name)
Systematic name
[DNA]-3′-diphospho-5′-guanosine hydrolase (guanosine 5′-phosphate-forming)
Comment
Aprataxin is a DNA-binding protein that catalyses (among other activities) the 3′ decapping of DNA-ppG (formed by EC 6.5.1.8, 3′-phosphate/5′-hydroxy nucleic acid ligase) [1]. The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and its eventual release. The enzyme also possesses the activity of EC 3.1.11.7, adenosine-5′-diphospho-5′-[DNA] diphosphatase, and EC 3.1.11.8, guanosine-5′-diphospho-5′-[DNA] diphosphatase.
History
created 2017, deleted 2019
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.2.1.1 created 1961, modified 1982, modified 2002, deleted 2005 1.2.1.6 created 1961, deleted 1965 1.2.1.14 created 1961, deleted 1984 1.2.1.35 created 1972, deleted 1984 1.2.1.37 created 1972, deleted 1984 1.2.1.55 created 1990, deleted 2003 1.2.1.56 created 1990, deleted 2003
