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EC 4.2.3.32 Details
EC number
4.2.3.32
Accepted name
levopimaradiene synthase
Reaction
(+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate
Other name(s)
PtTPS-LAS, LPS, copalyl-diphosphate diphosphate-lyase [abieta-8(14),12-diene-forming]
Systematic name
(+)-copalyl-diphosphate diphosphate-lyase [abieta-8(14),12-diene-forming]
Comment
In Ginkgo, the enzyme catalyses the initial cyclization step in the biosynthesis of ginkgolides, a structurally unique family of diterpenoids that are highly specific platelet-activating-factor receptor antagonists [1]. Levopimaradiene is widely distributed in higher plants. In some species the enzyme also forms abietadiene, palustradiene, and neoabietadiene [2].
History
created 2008, modified 2012
EC Tree
1.2.1.1 created 1961, modified 1982, modified 2002, deleted 2005
1.2.1.6 created 1961, deleted 1965
1.2.1.14 created 1961, deleted 1984
1.2.1.34 created 1972, deleted 1983 [transferred to EC 1.1.1.180, deleted 1984]
1.2.1.35 created 1972, deleted 1984
1.2.1.37 created 1972, deleted 1984
1.2.1.55 created 1990, deleted 2003
1.2.1.56 created 1990, deleted 2003