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EC 1.2.1.10 Details
EC number
1.2.1.10
Accepted name
acetaldehyde dehydrogenase (acetylating)
Reaction
acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+
Other name(s)
aldehyde dehydrogenase (acylating), ADA, acylating acetaldehyde dehyrogenase, DmpF, BphJ
Systematic name
acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)
CAS registry number
9028-91-5
Comment
Also acts, more slowly, on glycolaldehyde, propanal and butanal. In several bacterial species this enzyme forms a bifunctional complex with EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.87, propanal dehydrogenase (propanoylating). Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols. NADP+ can replace NAD+ but the rate of reaction is much slower [3].
History
created 1961, modified 2006, modified 2011
EC Tree
1.2.1.1 created 1961, modified 1982, modified 2002, deleted 2005
1.2.1.6 created 1961, deleted 1965
1.2.1.14 created 1961, deleted 1984
1.2.1.34 created 1972, deleted 1983 [transferred to EC 1.1.1.180, deleted 1984]
1.2.1.35 created 1972, deleted 1984
1.2.1.37 created 1972, deleted 1984
1.2.1.55 created 1990, deleted 2003
1.2.1.56 created 1990, deleted 2003