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EC 1.2.4.1 Details
EC number
1.2.4.1
Accepted name
pyruvate dehydrogenase (acetyl-transferring)
Reaction
pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
Other name(s)
pyruvate decarboxylase (ambiguous), pyruvate dehydrogenase (ambiguous), pyruvate dehydrogenase (lipoamide), pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating), pyruvic acid dehydrogenase, pyruvic dehydrogenase (ambiguous)
Systematic name
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
CAS registry number
9014-20-4
Comment
Contains thiamine diphosphate. It is a component (in multiple copies) of the multienzyme pyruvate dehydrogenase complex, EC 1.2.1.104, in which it is bound to a core of molecules of EC 2.3.1.12, dihydrolipoyllysine-residue acetyltransferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.
History
created 1961, modified 2003
EC Tree
1.2.99.1 created 1961, deleted 1984