Any feedback?
Please rate this page
(ecexplorer.php)
(0/150)

BRENDA support

EC Explorer

EC 4.2.3.152 Details
EC number
4.2.3.152
Accepted name
2-epi-5-epi-valiolone synthase
Reaction
α-D-sedoheptulopyranose 7-phosphate = 2-epi-5-epi-valiolone + phosphate
Other name(s)
AcbC, ValA, CetA, SalQ, C7-cyclitol synthase
Systematic name
α-D-sedoheptulopyranose-7-phosphate phosphate-lyase (cyclizing; 2-epi-5-epi-valiolone-forming)
Comment
The enzyme is highly specific for α-D-sedoheptulopyranose 7-phosphate. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. The enzyme is involved in the biosynthesis of C7N-aminocyclitol natural products, such as the valienamine moiety of the antidiabetic drug acarbose and the crop protectant validamycin A. cf. EC 4.2.3.155, 2-epi-valiolone synthase and EC 4.2.3.154, demethyl-4-deoxygadusol synthase.
History
created 2015, modified 2016
EC Tree
1.6.99.2 created 1961 as EC 1.6.5.2, transferred 1965 to EC 1.6.99.2, deleted 2005
1.6.99.4 created 1965, deleted 1972
1.6.99.7 created 1972, modified 1981 (EC 1.6.99.10 created 1978, incorporated 1981), deleted 2003
1.6.99.8 created 1972, deleted 2002
1.6.99.9 created 1972, deleted 2002
1.6.99.10 created 1978, deleted 1981
1.6.99.11 created 1989, deleted 2002
1.6.99.12 created 1989, deleted 2002
1.6.99.13 created 1992, deleted 2002