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EC 4.2.1.130 Details
EC number
4.2.1.130
Accepted name
D-lactate dehydratase
Reaction
(R)-lactate = 2-oxopropanal + H2O
Other name(s)
glyoxylase III, GLO3
Systematic name
(R)-lactate hydro-lyase
Comment
The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase).
History
created 2011
EC Tree
1.6.5.1 created 1961, deleted 1965