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EC 1.5.99.4 Details
EC number
1.5.99.4
Accepted name
nicotine dehydrogenase
Reaction
(S)-nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor
Other name(s)
nicotine oxidase, D-nicotine oxidase, nicotine:(acceptor) 6-oxidoreductase (hydroxylating), L-nicotine oxidase
Systematic name
nicotine:acceptor 6-oxidoreductase (hydroxylating)
CAS registry number
37256-31-8
Comment
A metalloprotein (FMN). The enzyme can act on both the naturally found (S)-enantiomer and the synthetic (R)-enantiomer of nicotine, with retention of configuration in both cases [4].
History
created 1972
EC Tree
1.6.5.1 created 1961, deleted 1965