Any feedback?
Please rate this page
(ecexplorer.php)
(0/150)

BRENDA support

EC Explorer

EC 1.14.19.20 Details
EC number
1.14.19.20
Accepted name
Δ7-sterol 5(6)-desaturase
Reaction
a Δ7-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ = a Δ5,7-sterol + 2 ferricytochrome b5 + 2 H2O
Other name(s)
lathosterol oxidase, Δ7-sterol Δ5-dehydrogenase, Δ7-sterol 5-desaturase, Δ7-sterol-C5(6)-desaturase, 5-DES, SC5DL (gene name), ERG3 (gene name)
Systematic name
Δ7-sterol,ferrocytochrome b5:oxygen oxidoreductase 5,6-dehydrogenating
CAS registry number
37255-37-1
Comment
This enzyme, found in eukaryotic organisms, catalyses the introduction of a double bond between the C5 and C6 carbons of the B ring of Δ7-sterols, to yield the corresponding Δ5,7-sterols. The enzymes from yeast, plants and vertebrates act on avenasterol, episterol, and lathosterol, respectively. The enzyme is located at the endoplasmic reticulum and is membrane bound.
History
created 1972 as EC 1.3.3.2, transferred 2005 to EC 1.14.21.6, transferred 2015 to EC 1.14.19.20
EC Tree