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EC 2.7.7.67 Details
EC number
2.7.7.67
Accepted name
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase
Reaction
CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
Other name(s)
carS (gene name), CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase, CTP:2,3-GG-GP ether cytidylyltransferase, CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase, CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol synthase, CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase, CDP-unsaturated archaeol synthase, CDP-archaeol synthase (incorrect)
Systematic name
CTP:2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate cytidylyltransferase
CAS registry number
329791-09-5
Comment
This enzyme catalyses one of the steps in the biosynthesis of polar lipids in archaea, which are characterized by having an sn-glycerol 1-phosphate backbone rather than an sn-glycerol 3-phosphate backbone as is found in bacteria and eukaryotes [1]. The enzyme requires Mg2+ and K+ for maximal activity [1].
History
created 2009, modified 2014
EC Tree
1.2.1.1 created 1961, modified 1982, modified 2002, deleted 2005
1.2.1.6 created 1961, deleted 1965
1.2.1.14 created 1961, deleted 1984
1.2.1.34 created 1972, deleted 1983 [transferred to EC 1.1.1.180, deleted 1984]
1.2.1.35 created 1972, deleted 1984
1.2.1.37 created 1972, deleted 1984
1.2.1.55 created 1990, deleted 2003
1.2.1.56 created 1990, deleted 2003