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EC 1.14.11.50 Details
EC number
1.14.11.50
Accepted name
(–)-deoxypodophyllotoxin synthase
Reaction
(–)-yatein + 2-oxoglutarate + O2 = (–)-deoxypodophyllotoxin + succinate + CO2 + H2O
Other name(s)
2-ODD (gene name)
Systematic name
(–)-yatein,2-oxoglutarate:oxygen oxidoreductase (ring-forming)
Comment
The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs. It catalyses the closure of the central six-membered ring in the aryltetralin scaffold.
History
created 2016, deleted 2018
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