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EC 2.7.1.169 Details
EC number
2.7.1.169
Accepted name
pantoate kinase
Reaction
ATP + (R)-pantoate = ADP + (R)-4-phosphopantoate
Other name(s)
PoK, TK2141 protein
Systematic name
ATP:(R)-pantoate 4-phosphotransferase
Comment
The conversion of (R)-pantoate to (R)-4′-phosphopantothenate is part of the pathway leading to biosynthesis of 4′-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with β-alanine, followed by phosphorylation (EC 6.3.2.1 and EC 2.7.1.33, respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with β-alanine.
History
created 2011
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