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EC 1.16.3.1 Details
EC number
1.16.3.1
Accepted name
ferroxidase
Reaction
4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O
Other name(s)
ceruloplasmin, caeruloplasmin, ferroxidase I, iron oxidase, iron(II):oxygen oxidoreductase, ferro:O2 oxidoreductase, iron II:oxygen oxidoreductase, hephaestin, HEPH
Systematic name
Fe(II):oxygen oxidoreductase
CAS registry number
9031-37-2, 104404-69-5
Comment
The enzyme in blood plasma (ceruloplasmin) belongs to the family of multicopper oxidases. In humans it accounts for 95% of plasma copper. It oxidizes Fe(II) to Fe(III), which allows the subsequent incorporation of the latter into proteins such as apotransferrin and lactoferrin. An enzyme from iron oxidizing bacterium strain TI-1 contains heme a.
History
created 1972, modified 2011
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