EC Explorer

1.1.1.356

GDP-L-colitose synthase

GDP-β-L-colitose + NAD(P)⁺ = GDP-4-dehydro-3,6-dideoxy-α-D-mannose + NAD(P)H + H⁺

ColC

GDP-β-L-colitose:NAD(P)⁺ 4-oxidoreductase (5-epimerizing)

The enzyme is involved in biosynthesis of L-colitose, a 3,6-dideoxyhexose found in the O-antigen of Gram-negative lipopolysaccharides, where it catalyses the reaction in the reverse direction. The enzyme also performs the NAD(P)H-dependent epimerisation at C-5 of the sugar. The enzyme from Yersinia pseudotuberculosis is Si-specific with respect to NAD(P)H [1].

created 2013