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EC 1.14.13.241 Details
show Brenda entryEC number
1.14.13.241
Accepted name
5-pyridoxate monooxygenase
Reaction
3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate + NADPH + H+ + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP+
Other name(s)
5-pyridoxate,NADPH:oxygen oxidoreductase (decyclizing),
5-pyridoxate oxidase (misleading),
5-pyridoxate dioxygenase (incorrect)
Systematic name
5-pyridoxate,NADPH:oxygen oxidoreductase (ring-opening)
CAS registry number
37256-70-5
Comment
Contains FAD. The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine (vitamin B6). Although the enzyme was initially thought to be a dioxygenase, oxygen-tracer experiments have suggested that it is a monooxygenase, incorporating only one oxygen atom from molecular oxygen into the product. The second oxygen atom originates from a water molecule, which is regenerated during the reaction and thus does not show up in the reaction equation.
History
created 2018 (EC 1.14.12.5 created 1972, incorporated 2018)
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.1.2 created 1965, deleted 1972 1.14.1.4 created 1965, deleted 1972 1.14.1.5 created 1965, deleted 1972 1.14.1.7 created 1965, deleted 1972 1.14.1.8 created 1965, deleted 1972 1.14.1.9 created 1965, deleted 1972 1.14.1.10 created 1965, deleted 1972 1.14.1.11 created 1965, deleted 1972
