EC Explorer

1.3.1.109

butanoyl-CoA dehydrogenase complex (NAD⁺, ferredoxin)

butanoyl-CoA + 2 NAD⁺ + 2 reduced ferredoxin [iron-sulfur] cluster = (E)-but-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster

bifurcating butyryl-CoA dehydrogenase, butyryl-CoA dehydrogenase/Etf complex, Etf-Bcd complex, bifurcating butanoyl-CoA dehydrogenase, butanoyl-CoA dehydrogenase/Etf complex, butanoyl-CoA dehydrogenase (NAD⁺, ferredoxin)

butanoyl-CoA:NAD⁺, ferredoxin oxidoreductase

The enzyme is a complex of a flavin-containing dehydrogenase component (Bcd) and an electron-transfer flavoprotein dimer (EtfAB). The enzyme complex, isolated from the bacteria Acidaminococcus fermentans and butanoate-producing Clostridia species, couples the exergonic reduction of (E)-but-2-enoyl-CoA to butanoyl-CoA by NADH to the endergonic reduction of ferredoxin by NADH, using electron bifurcation to overcome the steep energy barrier in ferredoxin reduction.

created 2015, modified 2021