EC Explorer

1.3.1.108

caffeoyl-CoA reductase

3-(3,4-dihydroxyphenyl)propanoyl-CoA + 2 NAD⁺ + 2 reduced ferredoxin [iron-sulfur] cluster = (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster

electron-bifurcating caffeoyl-CoA reductase, caffeoyl-CoA reductase-Etf complex, hydrocaffeoyl-CoA:NAD⁺,ferredoxin oxidoreductase

3-(3,4-dihydroxyphenyl)propanoyl-CoA:NAD⁺,ferredoxin oxidoreductase

The enzyme, characterized from the bacterium Acetobacterium woodii, contains two [4Fe-4S] clusters and FAD. The enzyme couples the endergonic ferredoxin reduction with NADH as reductant to the exergonic reduction of caffeoyl-CoA with the same reductant. It uses the mechanism of electron bifurcation to overcome the steep energy barrier in ferredoxin reduction. It also reduces 4-coumaroyl-CoA and feruloyl-CoA.

created 2015