EC Explorer
[browse EC tree] - [search]
EC 1.14.13.205 Details
show Brenda entryEC number
1.14.13.205
Accepted name
long-chain fatty acid ω-monooxygenase
Reaction
a long-chain fatty acid + NADPH + H+ + O2 = an ω-hydroxy-long-chain fatty acid + NADP+ + H2O
Other name(s)
CYP704B1 (gene name),
CYP52M1 (gene name),
CYP4A (gene name),
CYP86A (gene name)
Systematic name
long-chain fatty acid,NADPH:oxygen oxidoreductase (ω-hydroxylating)
Comment
The plant enzyme CYP704B1, which is involved in the synthesis of sporopollenin, a complex polymer found at the outer layer of spores and pollen, acts on palmitate (18:0), stearate (18:0) and oleate (18:1). The plant enzyme CYP86A1 also acts on laurate (12:0). The enzyme from the yeast Starmerella bombicola (CYP52M1) acts on C16 to C20 saturated and unsaturated fatty acids and can also hydroxylate the (ω-1) position. The mammalian enzyme CYP4A acts on laurate (12:0), myristate (14:0), palmitate (16:0), oleate (18:1), and arachidonate (20:4).
History
created 2015, deleted 2018
back to topEC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.1.2 created 1965, deleted 1972 1.14.1.4 created 1965, deleted 1972 1.14.1.5 created 1965, deleted 1972 1.14.1.7 created 1965, deleted 1972 1.14.1.8 created 1965, deleted 1972 1.14.1.9 created 1965, deleted 1972 1.14.1.10 created 1965, deleted 1972 1.14.1.11 created 1965, deleted 1972
