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EC 1.1.1.387 Details
show Brenda entryEC number
1.1.1.387
Accepted name
L-serine 3-dehydrogenase (NAD+)
Reaction
L-serine + NAD+ = 2-aminoacetaldehyde + CO2 + NADH + H+ (overall reaction);; (1a) L-serine + NAD+ = 2-aminomalonate semialdehyde + NADH + H+;; (1b) 2-aminomalonate semialdehyde = 2-aminoacetaldehyde + CO2 (spontaneous)
Other name(s)
NAD+-dependent L-serine dehydrogenase
Systematic name
L-serine:NAD+ 3-oxidoreductase
Comment
The enzyme, purified from the bacterium Pseudomonas aeruginosa, also shows activity with L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase). The enzyme has only very low activity with NADP+ [cf. EC 1.1.1.276, serine 3-dehydrogenase (NADP+)].
History
created 2015
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.1.2 created 1965, deleted 1972 1.14.1.4 created 1965, deleted 1972 1.14.1.5 created 1965, deleted 1972 1.14.1.7 created 1965, deleted 1972 1.14.1.8 created 1965, deleted 1972 1.14.1.9 created 1965, deleted 1972 1.14.1.10 created 1965, deleted 1972 1.14.1.11 created 1965, deleted 1972
