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EC 6.2.1.53 Details
EC number
6.2.1.53
Accepted name
L-proline—[L-prolyl-carrier protein] ligase
Reaction
ATP + L-proline + holo-[L-prolyl-carrier protein] = AMP + diphosphate + L-prolyl-[L-prolyl-carrier protein] (overall reaction);;(1a) ATP + L-proline = diphosphate + (L-prolyl)adenylate;;(1b) (L-prolyl)adenylate + holo-[L-prolyl-carrier protein] = AMP + L-prolyl-[L-prolyl-carrier protein]
Other name(s)
pltF (gene name), bmp4 (gene name), pigI (gene name)
Systematic name
L-proline:[L-prolyl-carrier protein] ligase (AMP-forming)
Comment
The enzyme participates in the biosynthesis of several pyrrole-containing compounds, such as undecylprodigiosin, prodigiosin, pyoluteorin, and coumermycin A1. It catalyses the activation of L-proline to an adenylate form, followed by its transfer to the 4′-phosphopantheine moiety of an L-prolyl-carrier protein.
History
created 2018
EC Tree
1.14.14.2 created 1972, deleted 1976
1.14.14.4 created 2000, deleted 2002