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EC 2.5.1.143 Details
EC number
2.5.1.143
Accepted name
pyridinium-3,5-biscarboxylic acid mononucleotide synthase
Reaction
deamido-NAD+ + hydrogencarbonate = AMP + pyridinium-3,5-biscarboxylate mononucleotide
Other name(s)
LarB, P2CMN synthase, nicotinic acid adenine dinucleotide carboxylase/hydrolase, NaAD carboxylase/hydrolase
Systematic name
deamido-NAD+:hydrogencarbonate nicotinate-β-D-ribonucleotidyltransferase
Comment
This enzyme, found in the bacterium Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. It carboxylates the pyridinium ring of deamido-NAD+ and cleaves the phosphoanhydride bond to release AMP and generate pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN).
History
created 2018
EC Tree
1.14.14.2 created 1972, deleted 1976
1.14.14.4 created 2000, deleted 2002