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EC 1.1.1.391 Details
EC number
1.1.1.391
Accepted name
3β-hydroxycholanate 3-dehydrogenase (NAD+)
Reaction
isolithocholate + NAD+ = 3-oxo-5β-cholan-24-oate + NADH + H+
Other name(s)
3β-hydroxysteroid dehydrogenase
Systematic name
isolithocholate:NAD+ 3-oxidoreductase
Comment
This bacterial enzyme is involved, along with EC 1.1.1.52, 3α-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3α-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bile acids to form 3β-bile acids (also known as iso-bile acids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bile acids. cf. EC 1.1.1.393, 3β-hydroxycholanate 3-dehydrogenase (NADP+).
History
created 2016
EC Tree
1.14.14.2 created 1972, deleted 1976
1.14.14.4 created 2000, deleted 2002