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EC 4.2.3.38 Details
EC number
4.2.3.38
Accepted name
α-bisabolene synthase
Reaction
(2E,6E)-farnesyl diphosphate = (E)-α-bisabolene + diphosphate
Other name(s)
bisabolene synthase
Systematic name
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-α-bisabolene-forming]
Comment
This cytosolic sesquiterpenoid synthase requires a divalent cation cofactor (Mg2+ or, to a lesser extent, Mn2+) to neutralize the negative charge of the diphosphate leaving group. While unlikely to encounter geranyl diphosphate (GDP) in vivo as it is localized to plastids, the enzyme can use GDP as a substrate in vitro to produce (+)-(4R)-limonene [cf. EC 4.2.3.20, (R)-limonene synthase]. The enzyme is induced as part of a defense mechanism in the grand fir Abies grandis as a response to stem wounding.
History
created 2009
EC Tree
1.14.14.2 created 1972, deleted 1976
1.14.14.4 created 2000, deleted 2002