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EC 1.14.19.13 Details
EC number
1.14.19.13
Accepted name
acyl-CoA 15-desaturase
Reaction
(9Z,12Z)-hexadeca-9,12-dienoyl-CoA + reduced acceptor + O2 = (9Z,12Z,15Z)-hexadeca-9,12,15-trienoyl-CoA + acceptor + 2 H2O
Other name(s)
DES3 (gene name)
Systematic name
acyl-CoA,reduced acceptor:oxygen oxidoreductase (15,16 cis-dehydrogenating)
Comment
The enzyme, characterized from the the plant Sorghum bicolor, is involved in the biosynthesis of sorgoleone, an allelopathic compound produced in root hair cells. The enzyme inserts a cis double bond at carbon 15. When acting on its natural substrate, (9Z,12Z)-hexadeca-9,12-dienoyl-CoA, it produces a product with a terminal double bond.
History
created 2015
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EC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.2 Acting on the aldehyde or oxo group of donors
1.3 Acting on the CH-CH group of donors
1.4 Acting on the CH-NH2 group of donors
1.5 Acting on the CH-NH group of donors
1.6 Acting on NADH or NADPH
1.7 Acting on other nitrogenous compounds as donors
1.8 Acting on a sulfur group of donors
1.9 Acting on a heme group of donors
1.10 Acting on diphenols and related substances as donors
1.11 Acting on a peroxide as acceptor
1.12 Acting on hydrogen as donor
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.1 With NADH or NADPH as one donor (deleted sub-subclass)
1.14.2 With ascorbate as one donor (deleted sub-subclass)
1.14.3 With reduced pteridine as one donor (deleted sub-subclass)
1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
1.14.19.1 stearoyl-CoA 9-desaturase
1.14.19.2 stearoyl-[acyl-carrier-protein] 9-desaturase
1.14.19.3 acyl-CoA 6-desaturase
1.14.19.4 acyl-lipid (11-3)-desaturase
1.14.19.5 acyl-CoA 11-(Z)-desaturase
1.14.19.6 acyl-CoA (9+3)-desaturase
1.14.19.7 (S)-2-hydroxypropylphosphonic acid epoxidase
1.14.19.8 pentalenolactone synthase
1.14.19.9 tryptophan 7-halogenase
1.14.19.10 icosanoyl-CoA 5-desaturase
1.14.19.11 acyl-[acyl-carrier-protein] 4-desaturase
1.14.19.12 acyl-lipid ω-(9-4) desaturase
1.14.19.13 acyl-CoA 15-desaturase
1.14.19.14 linoleoyl-lipid Δ9 conjugase
1.14.19.15 (11Z)-hexadec-11-enoyl-CoA conjugase
1.14.19.16 linoleoyl-lipid Δ12 conjugase (11E,13Z-forming)
1.14.19.17 sphingolipid 4-desaturase
1.14.19.18 sphingolipid 8-(E)-desaturase
1.14.19.19 sphingolipid 10-desaturase
1.14.19.20 Δ7-sterol 5(6)-desaturase
1.14.19.21 cholesterol 7-desaturase
1.14.19.22 acyl-lipid ω-6 desaturase (cytochrome b5)
1.14.19.23 acyl-lipid (n+3)-(Z)-desaturase (ferredoxin)
1.14.19.24 acyl-CoA 11-(E)-desaturase
1.14.19.25 acyl-lipid ω-3 desaturase (cytochrome b5)
1.14.19.26 acyl-[acyl-carrier-protein] 6-desaturase
1.14.19.27 sn-2 palmitoyl-lipid 9-desaturase
1.14.19.28 sn-1 stearoyl-lipid 9-desaturase
1.14.19.29 sphingolipid 8-(E/Z)-desaturase
1.14.19.30 acyl-lipid (8-3)-desaturase
1.14.19.31 acyl-lipid (7-3)-desaturase
1.14.19.32 palmitoyl-CoA 14-(E/Z)-desaturase
1.14.19.33 Δ12 acyl-lipid conjugase (11E,13E-forming)
1.14.19.34 acyl-lipid (9+3)-(E)-desaturase
1.14.19.35 sn-2 acyl-lipid ω-3 desaturase (ferredoxin)
1.14.19.36 sn-1 acyl-lipid ω-3 desaturase (ferredoxin)
1.14.19.37 acyl-CoA 5-desaturase
1.14.19.38 acyl-lipid Δ6-acetylenase
1.14.19.39 acyl-lipid Δ12-acetylenase
1.14.19.40 hex-5-enoyl-[acyl-carrier protein] acetylenase
1.14.19.41 sterol 22-desaturase
1.14.19.42 palmitoyl-[glycerolipid] 7-desaturase
1.14.19.43 palmitoyl-[glycerolipid] 3-(E)-desaturase
1.14.19.44 acyl-CoA (8-3)-desaturase
1.14.19.45 sn-1 oleoyl-lipid 12-desaturase
1.14.19.46 sn-1 linoleoyl-lipid 6-desaturase
1.14.19.47 acyl-lipid (9-3)-desaturase
1.14.19.48 tert-amyl alcohol desaturase
1.14.19.49 tetracycline 7-halogenase
1.14.19.50 noroxomaritidine synthase
1.14.19.51 (S)-corytuberine synthase
1.14.19.52 camalexin synthase
1.14.19.53 all-trans-retinol 3,4-desaturase
1.14.19.54 1,2-dehydroreticuline synthase
1.14.19.55 4-hydroxybenzoate brominase (decarboxylating)
1.14.19.56 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase
1.14.19.57 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase
1.14.19.58 tryptophan 5-halogenase
1.14.19.59 tryptophan 6-halogenase
1.14.19.60 7-chloro-L-tryptophan 6-halogenase
1.14.19.61 dihydrorhizobitoxine desaturase
1.14.19.62 secologanin synthase
1.14.19.63 pseudobaptigenin synthase
1.14.19.64 (S)-stylopine synthase
1.14.19.65 (S)-cheilanthifoline synthase
1.14.19.66 berbamunine synthase
1.14.19.67 salutaridine synthase
1.14.19.68 (S)-canadine synthase
1.14.19.69 biflaviolin synthase
1.14.19.70 mycocyclosin synthase
1.14.19.71 fumitremorgin C synthase
1.14.19.72 (–)-pluviatolide synthase
1.14.19.73 (S)-nandinine synthase
1.14.19.74 (+)-piperitol/(+)-sesamin synthase
1.14.19.75 very-long-chain acyl-lipid ω-9 desaturase
1.14.19.76 flavone synthase II
1.14.19.77 plasmanylethanolamine desaturase
1.14.19.78 decanoyl-[acyl-carrier protein] acetylenase
1.14.19.79 3β,22α-dihydroxysteroid 3-dehydrogenase
1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated
1.14.21 With NADH or NADPH as one donor, and the other dehydrogenated
1.14.99 Miscellaneous
1.15 Acting on superoxide as acceptor
1.16 Oxidizing metal ions
1.17 Acting on CH or CH2 groups
1.18 Acting on iron-sulfur proteins as donors
1.19 Acting on reduced flavodoxin as donor
1.20 Acting on phosphorus or arsenic in donors
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.21.1 With NAD+ or NADP+ as acceptor
1.21.3 With oxygen as acceptor
1.21.4 With a disulfide as acceptor
1.21.98 With other, known, physiological acceptors
1.21.99 With unknown physiological acceptors
1.22 Acting on halogen in donors
1.23 Reducing C-O-C group as acceptor
1.97 Other oxidoreductases
1.98 Enzymes using H2 as reductant (deleted subclass)
1.99 Other enzymes using O2 as oxidant (deleted subclass)
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.10.1 Acting on sulfur-nitrogen bonds (only sub-subclass identified to date)
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases