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EC 4.2.3.156 Details
EC number
4.2.3.156
Accepted name
hydroxysqualene synthase
Reaction
presqualene diphosphate + H2O = hydroxysqualene + diphosphate
Other name(s)
hpnC (gene name)
Systematic name
presqualene diphosphate diphosphate-lyase (adding water; hydroxyasqualene-forming)
Comment
This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 1.17.8.1, hydroxysqualene dehydroxylase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase.
History
created 2016
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