EC Explorer

7.2.4.2

oxaloacetate decarboxylase (Na⁺ extruding)

oxaloacetate + 2 Na⁺_{[side 1]} = pyruvate + CO₂ + 2 Na⁺_{[side 2]}

oxaloacetate β-decarboxylase (ambiguous), oxalacetic acid decarboxylase (ambiguous), oxalate β-decarboxylase (ambiguous), oxaloacetate carboxy-lyase (ambiguous)

oxaloacetate carboxy-lyase (pyruvate-forming; Na⁺-extruding)

9024-98-0

The enzyme from the bacterium Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA. The process is accompanied by the extrusion of two sodium ions from cells. Some animal enzymes require Mn²⁺. Differs from EC 4.1.1.112 (oxaloacetate decarboxylase) for which there is no evidence for involvement in Na⁺ transport.

created 1961 as EC 4.1.1.3, modified 1986, modified 2000, transferred 2018 to EC 7.2.4.2