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EC 6.2.1.54 Details
show Brenda entryEC number
6.2.1.54
Accepted name
D-alanine—[D-alanyl-carrier protein] ligase
Reaction
ATP + D-alanine + holo-[D-alanyl-carrier protein] = AMP + diphosphate + D-alanyl-[D-alanyl-carrier protein] (overall reaction);;(1a) ATP + D-alanine = (D-alanyl)adenylate + diphosphate;;(1b) (D-alanyl)adenylate + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein]
Other name(s)
dltA (gene name),
Dcl
Systematic name
D-alanine:[D-alanyl-carrier protein] ligase
Comment
The enzyme is involved in the modification of wall teichoic acids, as well as type I and IV lipoteichoic acids, with D-alanine residues. It activates D-alanine using ATP to form a high-energy (D-alanyl)adenylate intermediate and subsequently transfers the alanyl moiety to the phosphopantheinyl prosthetic group of a D-alanyl-carrier protein (DltC).
History
created 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
