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EC 3.2.1.207 Details
EC number
3.2.1.207
Accepted name
mannosyl-oligosaccharide α-1,3-glucosidase
Reaction
(1) Glc2Man9GlcNAc2-[protein] + H2O = GlcMan9GlcNAc2-[protein] + β-D-glucopyranose;;(2) GlcMan9GlcNAc2-[protein] + H2O = Man9GlcNAc2-[protein] + β-D-glucopyranose
Other name(s)
ER glucosidase II, α-glucosidase II, trimming glucosidase II, ROT2 (gene name), GTB1 (gene name), GANAB (gene name), PRKCSH (gene name)
Systematic name
Glc2Man9GlcNAc2-[protein] 3-α-glucohydrolase (configuration-inverting)
Comment
This eukaryotic enzyme cleaves off sequentially the two α-1,3-linked glucose residues from the Glc2Man9GlcNAc2 oligosaccharide precursor of immature N-glycosylated proteins.
History
created 2018
EC Tree
1.14.14.2 created 1972, deleted 1976
1.14.14.4 created 2000, deleted 2002