EC Explorer

4.3.2.8

γ-glutamylamine cyclotransferase

ε-(γ-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline

GGACT

ε-(γ-L-glutamyl)-L-lysine γ-glutamyl cyclotransferase (5-oxo-L-proline producing)

The enzyme, found in vertebrates, has no activity toward α-(γ-L-glutamyl)-L-amino acids (cf. EC 4.3.2.9, γ-glutamylcyclotransferase). The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the α-amine of the γ-L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.

created 2017