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EC 4.2.3.153 Details
EC number
4.2.3.153
Accepted name
(5-formylfuran-3-yl)methyl phosphate synthase
Reaction
2 D-glyceraldehyde 3-phosphate = (5-formylfuran-3-yl)methyl phosphate + phosphate + 2 H2O
Other name(s)
mfnB (gene name), 4-HFC-P synthase, 4-(hydroxymethyl)-2-furaldehyde phosphate synthase
Systematic name
D-glyceraldehyde-3-phosphate phosphate-lyase [D-glyceraldehyde-3-phosphate-adding; (5-formylfuran-3-yl)methyl-phosphate-forming]
Comment
The enzyme catalyses the reaction in the direction of producing (5-formylfuran-3-yl)methyl phosphate, an intermediate in the biosynthesis of methanofuran. The sequence of events starts with the removal of a phosphate group, followed by aldol condensation and cyclization. Methanofuran is a carbon-carrier cofactor involved in the first step of the methanogenic reduction of carbon dioxide by methanogenic archaea.
History
created 2015 as EC 4.1.99.21, transferred 2015 to EC 4.2.3.153
EC Tree
1.14.14.2 created 1972, deleted 1976
1.14.14.4 created 2000, deleted 2002