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EC 4.6.1.22 Details
show Brenda entryEC number
4.6.1.22
Accepted name
Bacillus subtilis ribonuclease
Reaction
RNA = a 5′-hydroxy-ribonucleotide + n nucleoside-2′,3′-cyclophosphates
Other name(s)
Proteus mirabilis RNase,
ribonucleate nucleotido-2′-transferase (cyclizing),
bacterial RNA lyase,
Bacillus subtilis intracellular ribonuclease
Systematic name
[RNA] 5′-hydroxy-ribonucleotide-3′-[RNA fragment]-lyase (cyclicizing; [RNA fragment]-3′- nucleoside -2′,3′-cyclophosphate-forming)
Comment
This enzyme catalyses endonucleolytic cleavage to 2′,3′-cyclic nucleotides. The cyclic products may be hydrolysed to the corresponding 3′-phosphates by 2′,3′-cyclic-nucleotide 2′-phosphodiesterase (EC 3.1.4.16). The enzyme from B. subtilis is inhibited by ATP.
History
created 1978 as EC 3.1.27.2, transferred 2028 to EC 4.6.1.22
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
