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EC 1.1.1.399 Details
show Brenda entryEC number
1.1.1.399
Accepted name
2-oxoglutarate reductase
Reaction
(R)-2-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH + H+
Other name(s)
serA (gene name)
Systematic name
(R)-2-hydroxyglutarate:NAD+ 2-oxidireductase
Comment
The enzyme catalyses a reversible reaction. The enzyme from the bacterium Peptoniphilus asaccharolyticus is specific for (R)-2-hydroxyglutarate [1,2]. The SerA enzyme from the bacterium Escherichia coli can also accept (S)-2-hydroxyglutarate with a much higher Km, and also catalyses the activity of EC 1.1.1.95, phosphoglycerate dehydrogenase [3].
History
created 2016
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
