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EC 6.3.4.22 Details
show Brenda entryEC number
6.3.4.22
Accepted name
tRNAIle2-agmatinylcytidine synthase
Reaction
ATP + agmatine + [tRNAIle2]-cytidine34 + H2O = [tRNAIle2]-2-agmatinylcytidine34 + AMP + 2 phosphate
Other name(s)
TiaS,
AF2259,
tRNAIle-2-agmatinylcytidine synthetase,
tRNAIle-agm2C synthetase,
tRNAIle-agmatidine synthetase
Systematic name
agmatine:[tRNAIle]-cytidine34 ligase
Comment
The enzyme from the archaeon Archaeoglobus fulgidus modifies the wobble base of the CAU anticodon of the archaeal tRNAIle2 at the oxo group in position 2 of cytidine34. This modification is crucial for accurate decoding of the genetic code. In bacteria EC 6.3.4.19, tRNAIle-lysidine synthase, catalyses the modification of [tRNAIle2]-cytidine34 to [tRNAIle2]-lysidine34 .
History
created 2013
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
