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EC 1.14.13.53 Details
show Brenda entryEC number
1.14.13.53
Accepted name
4′-methoxyisoflavone 2′-hydroxylase
Reaction
formononetin + NADPH + H+ + O2 = 2′-hydroxyformononetin + NADP+ + H2O
Other name(s)
isoflavone 2′-monooxygenase (ambiguous),
isoflavone 2′-hydroxylase (ambiguous)
Systematic name
formononetin,NADPH:oxygen oxidoreductase (2′-hydroxylating)
CAS registry number
110183-49-8
Comment
A heme-thiolate protein (P-450). Acts on isoflavones with a 4′-methoxy group, such as formononetin and biochanin A. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. EC 1.14.13.89, isoflavone 2′-hydroxylase, is less specific and acts on other isoflavones as well as 4′-methoxyisoflavones.
History
created 1992, modified 2005, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
