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EC 1.14.11.26 Details
EC number
1.14.11.26
Accepted name
deacetoxycephalosporin-C hydroxylase
Reaction
deacetoxycephalosporin C + 2-oxoglutarate + O2 = deacetylcephalosporin C + succinate + CO2
Other name(s)
deacetylcephalosporin C synthase, 3′-methylcephem hydroxylase, DACS, DAOC hydroxylase, deacetoxycephalosporin C hydroxylase
Systematic name
deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
CAS registry number
69772-89-0
Comment
Requires iron(II). The enzyme can also use 3-exomethylenecephalosporin C as a substrate to form deacetoxycephalosporin C, although more slowly [2]. In Acremonium chrysogenum, the enzyme forms part of a bifunctional protein along with EC 1.14.20.1, deactoxycephalosporin-C synthase. It is a separate enzyme in Streptomyces clavuligerus.
History
created 2005
EC Tree
1.14.12.2 created 1972, deleted 1990
1.14.12.6 created 1978, deleted 1999