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EC 4.2.3.149 Details
show Brenda entryEC number
4.2.3.149
Accepted name
nephthenol synthase
Reaction
geranylgeranyl diphosphate + H2O = (R)-nephthenol + diphosphate
Other name(s)
DtcycA (gene name),
DtcycB (gene name)
Systematic name
geranylgeranyl-diphosphate diphosphate-lyase [(R)-nephthenol-forming]
Comment
Requires Mg2+. Two isozymes with this activity were isolated from the bacterium Streptomyces sp. SANK 60404. The enzyme encoded by the DtcycA gene also produces cembrene C (see EC 4.2.3.148, cembrene C synthase), while the enzyme encoded by the DtcycB gene also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC 4.2.3.150, cembrene A synthase, and EC 4.2.3.151, pentamethylcyclopentadecatrienol synthase).
History
created 2014
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.11.5 created 1972, deleted 1976
