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EC 3.5.1.104 Details
EC number
3.5.1.104
Accepted name
peptidoglycan-N-acetylglucosamine deacetylase
Reaction
peptidoglycan-N-acetyl-D-glucosamine + H2O = peptidoglycan-D-glucosamine + acetate
Other name(s)
HP310,
PgdA,
SpPgdA,
BC1960,
peptidoglycan deacetylase,
N-acetylglucosamine deacetylase,
peptidoglycan GlcNAc deacetylase,
peptidoglycan N-acetylglucosamine deacetylase,
PG N-deacetylase
Systematic name
peptidoglycan-N-acetylglucosamine amidohydrolase
Comment
Modification of peptidoglycan by N-deacetylation is an important factor in virulence of Helicobacter pylori, Listeria monocytogenes and Streptococcus suis [4-6]. The enzyme from Streptococcus pneumoniae is a metalloenzyme using a His-His-Asp zinc-binding triad with a nearby aspartic acid and histidine acting as the catalytic base and acid, respectively [3].
History
created 2010
EC Tree
1.14.11.5 created 1972, deleted 1976