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EC 1.14.11.2 Details
EC number
1.14.11.2
Accepted name
procollagen-proline 4-dioxygenase
Reaction
procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2
Other name(s)
P4HA (gene name),
P4HB (gene name),
protocollagen hydroxylase,
proline hydroxylase,
proline,2-oxoglutarate 4-dioxygenase,
collagen proline hydroxylase,
hydroxylase, collagen proline,
peptidyl proline hydroxylase,
proline protocollagen hydroxylase,
proline, 2-oxoglutarate dioxygenase,
prolyl hydroxylase,
prolylprotocollagen dioxygenase,
prolylprotocollagen hydroxylase,
protocollagen proline 4-hydroxylase,
protocollagen proline dioxygenase,
protocollagen proline hydroxylase,
protocollagen prolyl hydroxylase,
prolyl 4-hydroxylase,
prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating,
procollagen-proline 4-dioxygenase (ambiguous)
Systematic name
procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)
CAS registry number
9028-06-2
Comment
Requires Fe2+ and ascorbate.The enzyme, which is located within the lumen of the endoplasmic reticulum, catalyses the 4-hydroxylation of prolines in -X-Pro-Gly- sequences. The 4-hydroxyproline residues are essential for the formation of the collagen triple helix. The enzyme forms a complex with protein disulfide isomerase and acts not only on procollagen but also on more than 15 other proteins that have collagen-like domains.
History
created 1972, modified 1981, modified 1983, modified 2017
EC Tree
1.14.11.5 created 1972, deleted 1976