EC Explorer

1.5.1.53

methylenetetrahydrofolate reductase (NADPH)

5-methyltetrahydrofolate + NADP⁺ = 5,10-methylenetetrahydrofolate + NADPH + H⁺

MTHFR (gene name), methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase, 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase (ambiguous), 5,10-CH₂-H₄folate reductase (ambiguous), methylenetetrahydrofolate reductase (NADPH₂), 5,10-methylenetetrahydrofolate reductase (ambiguous), methylenetetrahydrofolate reductase (ambiguous), N⁵,10-methylenetetrahydrofolate reductase (ambiguous), 5,10-methylenetetrahydropteroylglutamate reductase (ambiguous), N⁵,N¹⁰-methylenetetrahydrofolate reductase (ambiguous), methylenetetrahydrofolic acid reductase (ambiguous), 5-methyltetrahydrofolate:(acceptor) oxidoreductase (incorrect), 5,10-methylenetetrahydrofolate reductase (FADH₂) (ambiguous)

5-methyltetrahydrofolate:NADP⁺ oxidoreductase

71822-25-8

A flavoprotein (FAD). The enzyme from yeast and mammals catalyses a physiologically irreversible reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using NADPH as the electron donor. It plays an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis. The enzyme contains an N-terminal catalytic domain and a C-terminal allosteric regulatory domain that binds S-adenosyl-L-methionine, which acts as an inhibitor. cf. EC 1.5.1.54, methylenetetrahydrofolate reductase (NADH); EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H]; and EC 1.5.7.1, methylenetetrahydrofolate reductase (ferredoxin).

created 2021