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EC 3.1.4.37 Details
show Brenda entryEC number
3.1.4.37
Accepted name
2′,3′-cyclic-nucleotide 3′-phosphodiesterase
Reaction
nucleoside 2′,3′-cyclic phosphate + H2O = nucleoside 2′-phosphate
Other name(s)
cyclic-CMP phosphodiesterase,
2′,3′-cyclic AMP phosphodiesterase,
cyclic 2′,3′-nucleotide 3′-phosphodiesterase,
cyclic 2′,3′-nucleotide phosphodiesterase,
2′,3′-cyclic nucleoside monophosphate phosphodiesterase,
2′,3′-cyclic nucleotide 3′-phosphohydrolase,
CNPase,
2′,3′-cyclic nucleotide phosphohydrolase,
2′:3′-cyclic nucleotide 3′-phosphodiesterase,
2′:3′-CNMP-3′-ase
Systematic name
nucleoside-2′,3′-cyclic-phosphate 2′-nucleotidohydrolase
CAS registry number
60098-35-3
Comment
The brain enzyme acts on 2′,3′-cyclic AMP more rapidly than on the UMP or CMP derivatives. An enzyme from liver acts on 2′,3′-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyses the corresponding 3′,5′-cyclic phosphates, but more slowly. This latter enzyme has been called cyclic-CMP phosphodiesterase.
History
created 1976
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
3.1.6.5 created 1961, deleted 1964
