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EC 3.1.4.1 Details
show Brenda entryEC number
3.1.4.1
Accepted name
phosphodiesterase I
Reaction
Hydrolytically removes 5′-nucleotides successively from the 3′-hydroxy termini of 3′-hydroxy-terminated oligonucleotides
Other name(s)
5′-exonuclease,
5′-phosphodiesterase,
5′-nucleotide phosphodiesterase,
oligonucleate 5′-nucleotidohydrolase,
5&prime,
nucleotide phosphodiesterase/alkaline phosphodiesterase I,
5′-NPDase,
5′-PDase,
5′-PDE,
5’NPDE,
alkaline phosphodiesterase,
nucleotide pyrophosphatase/phosphodiesterase I,
orthophosphoric diester phosphohydrolase,
PDE I,
phosphodiesterase (ambiguous),
exonuclease I
Systematic name
oligonucleotide 5′-nucleotidohydrolase
CAS registry number
9025-82-5
Comment
Hydrolyses both ribonucleotides and deoxyribonucleotides. Has low activity towards polynucleotides. A 3′-phosphate terminus on the substrate inhibits hydrolysis.
History
created 1961
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
3.1.4.5 created 1961, deleted 1978 3.1.4.6 created 1961, deleted 1978 3.1.4.7 created 1961, deleted 1978 3.1.4.9 created 1965, deleted 1978 3.1.4.10 created 1972, modified 1976, deleted 2002 3.1.4.18 created 1972, deleted 1978 3.1.4.19 created 1972, deleted 1978 3.1.4.20 created 1972, deleted 1978 3.1.4.21 created 1972, deleted 1978 3.1.4.22 created 1972, deleted 1978 3.1.4.23 created 1972, deleted 1978 3.1.4.24 created 1972, deleted 1978 3.1.4.25 created 1972, deleted 1978 3.1.4.26 created 1972, deleted 1978 3.1.4.27 created 1972, deleted 1978 3.1.4.28 created 1972, deleted 1978 3.1.4.29 created 1972, deleted 1978 3.1.4.30 created 1972, deleted 1978 3.1.4.31 created 1972, deleted 1978 3.1.4.32 created 1972, deleted 1978 3.1.4.33 created 1972, deleted 1978 3.1.4.34 created 1972, deleted 1978 3.1.4.36 created 1976, deleted 2002 3.1.4.47 created 1989, deleted 2002
