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EC 2.4.99.20 Details
EC number
2.4.99.20
Accepted name
2′-phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase
Reaction
NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide (overall reaction);;(1a) NADP+ = 2′-phospho-cyclic ADP-ribose + nicotinamide;;(1b) 2′-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate
Other name(s)
diphosphopyridine nucleosidase (ambiguous), CD38 (gene name), BST1 (gene name)
Systematic name
NADP+:nicotinate ADP-ribosyltransferase
Comment
This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2′-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
History
created 2014
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EC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.2 Acting on the aldehyde or oxo group of donors
1.3 Acting on the CH-CH group of donors
1.4 Acting on the CH-NH2 group of donors
1.5 Acting on the CH-NH group of donors
1.6 Acting on NADH or NADPH
1.7 Acting on other nitrogenous compounds as donors
1.8 Acting on a sulfur group of donors
1.9 Acting on a heme group of donors
1.10 Acting on diphenols and related substances as donors
1.11 Acting on a peroxide as acceptor
1.12 Acting on hydrogen as donor
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.15 Acting on superoxide as acceptor
1.16 Oxidizing metal ions
1.17 Acting on CH or CH2 groups
1.18 Acting on iron-sulfur proteins as donors
1.19 Acting on reduced flavodoxin as donor
1.20 Acting on phosphorus or arsenic in donors
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.21.1 With NAD+ or NADP+ as acceptor
1.21.3 With oxygen as acceptor
1.21.4 With a disulfide as acceptor
1.21.98 With other, known, physiological acceptors
1.21.99 With unknown physiological acceptors
1.22 Acting on halogen in donors
1.23 Reducing C-O-C group as acceptor
1.97 Other oxidoreductases
1.98 Enzymes using H2 as reductant (deleted subclass)
1.99 Other enzymes using O2 as oxidant (deleted subclass)
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.1.1 Carboxylic-ester hydrolases
3.1.2 Thioester hydrolases
3.1.3 Phosphoric-monoester hydrolases
3.1.3.1 alkaline phosphatase
3.1.3.2 acid phosphatase
3.1.3.3 phosphoserine phosphatase
3.1.3.4 phosphatidate phosphatase
3.1.3.5 5′-nucleotidase
3.1.3.6 3′-nucleotidase
3.1.3.7 3′(2′),5′-bisphosphate nucleotidase
3.1.3.8 3-phytase
3.1.3.9 glucose-6-phosphatase
3.1.3.10 glucose-1-phosphatase
3.1.3.11 fructose-bisphosphatase
3.1.3.12 trehalose-phosphatase
3.1.3.13 bisphosphoglycerate phosphatase
3.1.3.14 methylphosphothioglycerate phosphatase
3.1.3.15 histidinol-phosphatase
3.1.3.16 protein-serine/threonine phosphatase
3.1.3.17 [phosphorylase] phosphatase
3.1.3.18 phosphoglycolate phosphatase
3.1.3.19 glycerol-2-phosphatase
3.1.3.20 phosphoglycerate phosphatase
3.1.3.21 glycerol-1-phosphatase
3.1.3.22 mannitol-1-phosphatase
3.1.3.23 sugar-phosphatase
3.1.3.24 sucrose-phosphate phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.26 4-phytase
3.1.3.27 phosphatidylglycerophosphatase
3.1.3.28 ADP-phosphoglycerate phosphatase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.30 created 1972, deleted 1992
3.1.3.31 nucleotidase
3.1.3.32 polynucleotide 3′-phosphatase
3.1.3.33 polynucleotide 5′-phosphatase
3.1.3.34 deoxynucleotide 3′-phosphatase
3.1.3.35 thymidylate 5′-phosphatase
3.1.3.36 phosphoinositide 5-phosphatase
3.1.3.37 sedoheptulose-bisphosphatase
3.1.3.38 3-phosphoglycerate phosphatase
3.1.3.39 streptomycin-6-phosphatase
3.1.3.40 guanidinodeoxy-scyllo-inositol-4-phosphatase
3.1.3.41 4-nitrophenylphosphatase
3.1.3.42 [glycogen-synthase-D] phosphatase
3.1.3.43 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase
3.1.3.44 [acetyl-CoA carboxylase]-phosphatase
3.1.3.45 3-deoxy-manno-octulosonate-8-phosphatase
3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase
3.1.3.47 [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase
3.1.3.48 protein-tyrosine-phosphatase
3.1.3.49 [pyruvate kinase]-phosphatase
3.1.3.50 sorbitol-6-phosphatase
3.1.3.51 dolichyl-phosphatase
3.1.3.52 [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase
3.1.3.53 [myosin-light-chain] phosphatase
3.1.3.54 fructose-2,6-bisphosphate 6-phosphatase
3.1.3.55 caldesmon-phosphatase
3.1.3.56 inositol-polyphosphate 5-phosphatase
3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase
3.1.3.58 sugar-terminal-phosphatase
3.1.3.59 alkylacetylglycerophosphatase
3.1.3.60 phosphoenolpyruvate phosphatase
3.1.3.61 created 1992, deleted 2002
3.1.3.62 multiple inositol-polyphosphate phosphatase
3.1.3.63 2-carboxy-D-arabinitol-1-phosphatase
3.1.3.64 phosphatidylinositol-3-phosphatase
3.1.3.65 created 1992, deleted 2002
3.1.3.66 phosphatidylinositol-3,4-bisphosphate 4-phosphatase
3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
3.1.3.68 2-deoxyglucose-6-phosphatase
3.1.3.69 glucosylglycerol 3-phosphatase
3.1.3.70 mannosyl-3-phosphoglycerate phosphatase
3.1.3.71 2-phosphosulfolactate phosphatase
3.1.3.72 5-phytase
3.1.3.73 adenosylcobalamin/α-ribazole phosphatase
3.1.3.74 pyridoxal phosphatase
3.1.3.75 phosphoethanolamine/phosphocholine phosphatase
3.1.3.76 lipid-phosphate phosphatase
3.1.3.77 acireductone synthase
3.1.3.78 phosphatidylinositol-4,5-bisphosphate 4-phosphatase
3.1.3.79 mannosylfructose-phosphate phosphatase
3.1.3.80 2,3-bisphosphoglycerate 3-phosphatase
3.1.3.81 diacylglycerol diphosphate phosphatase
3.1.3.82 D-glycero-β-D-manno-heptose 1,7-bisphosphate 7-phosphatase
3.1.3.83 D-glycero-α-D-manno-heptose 1,7-bisphosphate 7-phosphatase
3.1.3.84 ADP-ribose 1′′-phosphate phosphatase
3.1.3.85 glucosyl-3-phosphoglycerate phosphatase
3.1.3.86 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
3.1.3.87 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase
3.1.3.88 5′′-phosphoribostamycin phosphatase
3.1.3.89 5′-deoxynucleotidase
3.1.3.90 maltose 6′-phosphate phosphatase
3.1.3.91 7-methylguanosine nucleotidase
3.1.3.92 kanosamine-6-phosphate phosphatase
3.1.3.93 L-galactose 1-phosphate phosphatase
3.1.3.94 D-galactose 1-phosphate phosphatase
3.1.3.95 phosphatidylinositol-3,5-bisphosphate 3-phosphatase
3.1.3.96 pseudouridine 5′-phosphatase
3.1.3.97 3′,5′-nucleoside bisphosphate phosphatase
3.1.3.98 geranyl diphosphate phosphohydrolase
3.1.3.99 IMP-specific 5′-nucleotidase
3.1.3.100 thiamine phosphate phosphatase
3.1.3.101 validoxylamine A 7′-phosphate phosphatase
3.1.3.102 FMN hydrolase
3.1.3.103 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase
3.1.3.104 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase
3.1.3.105 N-acetyl-D-muramate 6-phosphate phosphatase
3.1.3.106 2-lysophosphatidate phosphatase
3.1.3.107 amicoumacin phosphatase
3.1.3.108 nocturnin
3.1.4 Phosphoric-diester hydrolases
3.1.5 Triphosphoric-monoester hydrolases
3.1.6 Sulfuric-ester hydrolases
3.1.7 Diphosphoric-monoester hydrolases
3.1.8 Phosphoric-triester hydrolases
3.1.11 Exodeoxyribonucleases producing 5′-phosphomonoesters
3.1.12 Exodeoxyribonucleases producing 3′-phosphomonoesters
3.1.13 Exoribonucleases producing 5′-phosphomonoesters
3.1.14 Exoribonucleases producing 3'-phosphomonoesters
3.1.15 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
3.1.16 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters
3.1.22 Endodeoxyribonucleases producing 3'-phosphomonoesters
3.1.23 Site-specific endodeoxyribonucleases: cleavage is sequence specific (deleted sub-subclass)
3.1.24 Site specific endodeoxyribonucleases: cleavage is not sequence specific (deleted sub-subclass)
3.1.25 Site-specific endodeoxyribonucleases that are specific for altered bases
3.1.26 Endoribonucleases producing 5'-phosphomonoesters
3.1.27 Endoribonucleases producing 3'-phosphomonoesters
3.1.30 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
3.1.31 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.10.1 Acting on sulfur-nitrogen bonds (only sub-subclass identified to date)
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases