Any feedback?
Please rate this page
(ecexplorer.php)
(0/150)

BRENDA support

EC Explorer

EC 1.21.3.9 Details
EC number
1.21.3.9
Accepted name
dichlorochromopyrrolate synthase
Reaction
4 2-imino-3-(7-chloroindol-3-yl)propanoate + O2 = 2 dichlorochromopyrrolate + 2 NH3 + 2 H2O
Other name(s)
RebD, chromopyrrolic acid synthase, chromopyrrolate synthase
Systematic name
2-imino-3-(7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming)
Comment
This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a dimeric heme-protein oxidase that catalyses the oxidative dimerization of two L-tryptophan-derived molecules to form dichlorochromopyrrolic acid, the precursor for the fused six-ring indolocarbazole scaffold of rebeccamycin [1]. Contains one molecule of heme b per monomer, as well as non-heme iron that is not part of an iron-sulfur center [2]. The enzyme also possesses catalase activity, suggesting that the secondary product may be hydrogen peroxide rather than water. The nature of the secondary product has not been confirmed as of 2013.
History
created 2010 as EC 4.3.1.26, transferred 2013 to EC 1.21.3.9, deleted 2016
EC Tree
3.1.3.30 created 1972, deleted 1992
3.1.3.61 created 1992, deleted 2002
3.1.3.65 created 1992, deleted 2002