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EC 4.2.3.132 Details
EC number
4.2.3.132
Accepted name
neoabietadiene synthase
Reaction
(+)-copalyl diphosphate = neoabietadiene + diphosphate
Other name(s)
TPS-LAS
Systematic name
(+)-copaly-diphosphate diphosphate-lyase (cyclizing, neoabietadiene-forming)
Comment
Isolated from Abies grandis (grand fir) [1]. This class I enzyme forms about equal proportions of abietadiene, levopimaradiene and neoabietadiene. See also EC 4.2.3.18, abieta-7,13-diene synthase and EC 4.2.3.32, levopimaradiene synthase. An X-ray study of this multifunctional enzyme showed that the class I activity is in the α domain, while (+)-copalyl diphosphate synthase activity (EC 5.5.1.12, a class II activity) is in the β and γ domains [2]. In Pinus taeda (loblolly pine) the major product is levopimaradiene, with less abietadiene and neoabietadiene [3].
History
created 2012
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