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EC 1.3.1.39 Details
EC number
1.3.1.39
Accepted name
enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
Reaction
an acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
Other name(s)
acyl-ACP dehydrogenase, enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase, NADPH 2-enoyl Co A reductase, enoyl-ACp reductase, enoyl-[acyl-carrier-protein] reductase (NADPH2, A-specific), acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (A-specific), enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific), acyl-[acyl-carrier protein]:NADP+ oxidoreductase (A-specific)
Systematic name
acyl-[acyl-carrier protein]:NADP+ oxidoreductase (Re-specific)
Comment
This enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to an acyl-carrier protein. It is one of the activities of EC 2.3.1.85, fatty-acid synthase system. The mammalian enzyme is Re-specific with respect to NADP+. cf. EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.3.1.104, enoyl-[acyl-carrier-protein] reductase (NADPH).
History
created 1986, modified 2013, modified 2018
EC Tree
1.3.1.23 created 1972, deleted 2005
1.3.1.50 created 1992, deleted 1999
1.3.1.55 created 1999, deleted 2004