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EC 1.3.1.3 Details
EC number
1.3.1.3
Accepted name
Δ4-3-oxosteroid 5β-reductase
Reaction
(1) 5β-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+;;(2) 17,21-dihydroxy-5β-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+
Other name(s)
3-oxo-Δ4-steroid 5β-reductase, 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ4-3-ketosteroid 5β-reductase, Δ4-5β-reductase, Δ4-hydrogenase, 4,5β-dihydrocortisone:NADP+ Δ4-oxidoreductase, 3-oxo-5β-steroid:NADP+ Δ4-oxidoreductase
Systematic name
5β-cholestan-3-one:NADP+ 4,5-oxidoreductase
CAS registry number
9029-08-7
Comment
The enzyme from human efficiently catalyses the reduction of progesterone, androstenedione, 17α-hydroxyprogesterone and testosterone to 5β-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent [8]. The bile acid intermediates 7α,12α-dihydroxy-4-cholesten-3-one and 7α-hydroxy-4-cholesten-3-one can also act as substrates [9].
History
created 1961 (EC 1.3.1.23 created 1972, incorporated 2005), modified 2005
EC Tree
1.3.1.23 created 1972, deleted 2005
1.3.1.50 created 1992, deleted 1999
1.3.1.55 created 1999, deleted 2004