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EC 4.2.1.157 Details
EC number
4.2.1.157
Accepted name
(R)-2-hydroxyisocaproyl-CoA dehydratase
Reaction
(R)-2-hydroxy-4-methylpentanoyl-CoA = 4-methylpent-2-enoyl-CoA + H2O
Other name(s)
2-hydroxyisocaproyl-CoA dehydratase,
HadBC
Systematic name
(R)-2-hydroxy-4-methylpentanoyl-CoA hydro-lyase
Comment
The enzyme, isolated from the bacterium Peptoclostridium difficile, is involved in the reductive branch of L-leucine fermentation. It catalyses an α/β-dehydration, which depends on the reductive formation of ketyl radicals on the substrate generated by injection of a single electron from the ATP-dependent activator protein HadI.
History
created 2015
EC Tree
1.3.1.23 created 1972, deleted 2005
1.3.1.50 created 1992, deleted 1999
1.3.1.55 created 1999, deleted 2004