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EC 4.2.1.139 Details
show Brenda entryEC number
4.2.1.139
Accepted name
pterocarpan synthase
Reaction
a (4R)-4,2′-dihydroxyisoflavan = a pterocarpan + H2O
Other name(s)
medicarpin synthase,
medicarpan synthase,
7,2′-dihydroxy-4′-methoxyisoflavanol dehydratase,
2′,7-dihydroxy-4′-methoxyisoflavanol dehydratase,
DMI dehydratase,
DMID,
2′-hydroxyisoflavanol 4,2′-dehydratase,
PTS (gene name),
4′-methoxyisoflavan-2′,4,7-triol hydro-lyase [(–)-medicarpin-forming]
Systematic name
(4R)-4,2′-dihydroxyisoflavan hydro-lyase (pterocarpan-forming)
Comment
The enzyme catalyses the formation of the additional ring in pterocarpan, the basic structure of phytoalexins produced by leguminous plants, including (–)-medicarpin, (+)-medicarpin, (–)-maackiain and (+)-maackiain. The enzyme requires that the hydroxyl group at C-4 of the substrate is in the (4R) configuration. The configuration of the hydrogen atom at C-3 determines whether the pterocarpan is the (+)- or (–)-enantiomer. The enzyme contains amino acid motifs characteristic of dirigent proteins.
History
created 2013, modified 2019
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.3.1.23 created 1972, deleted 2005 1.3.1.50 created 1992, deleted 1999 1.3.1.55 created 1999, deleted 2004
