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EC 3.9.1.3 Details
EC number
3.9.1.3
Accepted name
phosphohistidine phosphatase
Reaction
a [protein]-N-phospho-L-histidine + H2O = a [protein]-L-histidine + phosphate
Other name(s)
PHPT1 (gene name), protein histidine phosphatase, PHP
Systematic name
[protein]-N-phospho-L-histidine phosphohydrolase
Comment
This eukaryotic enzyme dephosphorylates phosphorylated histidine residues within proteins and peptides. The enzyme acts on phosphate groups attached to both the pros- and tele-nitrogen atoms, but the pros- position is somewhat preferred (by a factor of two at the most) [4]. The substrate specificity depends on the amino acid sequence or structural context of the phosphohistidine in a phosphoprotein. The enzyme is also active on free phosphoramidate [1,4] and peptide-bound phospholysine [5].
History
created 2016
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